| 中文名称: |
(2-巯基乙基)-胍硫酸盐 |
| 英文名称: |
MEG hemisulfate |
| 产品分类: |
小分子化合物(化合物库) |
| CAS号: |
3979-00-8 |
| 分子式: |
C6H20N6O4S3 |
| 分子量: |
336.46 |
*产品基础信息:
【产品中文名称】(2-巯基乙基)-胍硫酸盐;
【产品英文名称】MEG hemisulfate;
【纯度指标】99.81%;
【品牌】TargetMol;
【CAS号】3979-00-8;
【浓度】;
Product Introduction
Bioactivity
| 名称 | MEG hemisulfate |
| 描述 | MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock. |
| 体外活性 | MEG (0.1-1000 μM; 18 h) reduces nitrite accumulation in the supernatant of cultured J774.2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL). MEG inhibits iNOS activity in homogenates of lungs taken from LPS-treated rats[1]. MEG (1 μM-3 mM; 3 min) dose-dependently inhibits the peroxynitrite-induced oxidation of cytochrome c2+ and hydroxylation of benzoate. MEG (1-300 μM) inhibits the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite in J774 cells. MEG (300 μM; 30 min) inhibits the suppression of vascular contractility in response to peroxynitrite in thoracic aortic rings[2]. |
| 体内活性 | MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats[1]. MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury[3]. MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney[4]. |
| 存储条件 | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 45 mg/mL (133.75 mM), Sonication is recommended.
|
| 关键字 | Mercaptoethylguanidine Hemisulfate | Mercaptoethylguanidine | MEG Hemisulfate | MEG | iNOS |
| 相关产品 | Aminopicoline | Diallyl disulfide | Methylene Blue trihydrate | Agmatine sulfate | Chondroitin sulfate | Gluconate Calcium | Gluconate sodium | L-Arginine | 2-Isopropyl-1H-imidazole | Magnesium sulfate | 3-AMINO-1,2,4-TRIAZINE | Nitroarginine |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Immunology/Inflammation Compound Library | Bioactive Compound Library Plus |





























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